An Autopsy Case of Clostridium Perfringens Septicemia Accompanied by Perforation of the Sigmoid Colon

DOI 1 Citations 13 References
  • Kai Keita
    Department of Surgery, Saga University Faculty of Medicine Department of Pathology & Biodefense, Saga University Faculty of Medicine
  • Kobayashi Kiichiro
    Department of Surgery, Saga University Faculty of Medicine
  • Urata Masako
    Department of Surgery, Saga University Faculty of Medicine
  • Motomura Tomokazu
    Department of Emergency Medicine, Saga University Faculty of Medicine
  • Noshiro Hirokazu
    Department of Surgery, Saga University Faculty of Medicine
  • Miyazaki Kohji
    Department of Surgery, Saga University Faculty of Medicine

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  • 大腸穿孔で発症し，急激な転帰をたどったClostridium perfringens感染症の一剖検例

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A 67-year-old man complaining of severe diarrhea and abdominal pain was admitted to our hospital. He had a history of undergoing a distal gastrectomy ten years previously. An operation was performed under the diagnosis of large bowel perforation, and a perforation of the sigmoid colon was intraoperatively found. Despite intensive care, he died of sepsis and type A Clostridium perfringens was detected from his blood and the perforated colon. C. perfringens infection accompanied by gastrointestinal perforation is extremely rare. The type A C. perfringens has sometimes caused sitotoxism but its prognosis is usually good. On the other hand, C. perfringens septicemia is fatal and causes severe hemolysis and disseminated intravascular coagulation. C. perfringens infection should be considered in the case of acute abdomen with severe diarrhea for the early initiation of active treatment and for the prevention of C. perfringens-mediated septicemia.

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