A Suspected Case of Relapsing Polychondritis Manifesting After Laryngeal Cancer Treatment

DOI
  • Fukuhara Atsuro
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Oshima Kengo
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Tanino Yoshinori
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Minemura Hiroyuki
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Nikaido Takefumi
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Ishii Taeko
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Sato Suguru
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Yokouchi Hiroshi
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Kanazawa Kenya
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Ishida Takashi
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine
  • Munakata Mitsuru
    Department of Pulmonary Medicine, Fukushima Medical University School of Medicine

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Other Title
  • 喉頭癌治療後に顕在化し,再発性多発軟骨炎が疑われた1例

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Abstract

Background. Relapsing polychondritis (RPC) causes chronic inflammation and degeneration in systemic cartilage tissue, particularly in the ear auricles, nose and trachea. The etiology of this condition is unknown, although it is suspected to be an autoimmune problem. Case. An 80-year-old male had undergone total laryngectomy for laryngeal cancer and received postoperative radiation therapy for residual cancer. Following irradiation, he developed dyspnea and wheezing and was referred to our department. Short-term steroid therapy improved his symptoms temporarily; however, his condition relapsed several times after the cessation of medication. He was therefore admitted to our department for further investigation and treatment. A chest computed tomography scan showed thickening of the tracheal and bilateral bronchial walls with collapse of the lumen. A bronchoscopic examination revealed redness of the entire circumference of the tracheal mucosa with stenosis of the tracheal lumen and collapse of the bilateral main bronchial lumen. Based on these findings, the patient was suspected to have early-stage RPC. Treatment with long-term corticosteroid therapy improved his dyspnea, wheezing and exercise tolerability. Conclusions. We herein report a suspected case of RPC that manifested after surgical treatment and radiation therapy for laryngeal cancer.

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