Plasma amino acid levels in acute hepatic failure

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  • Hirose Tomoya
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Shimizu Kentaro
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Ogura Hiroshi
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Yamano Shuhei
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Ohnishi Mitsuo
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Kuwagata Yasuyuki
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Shimazu Takeshi
    Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine

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  • 急性肝不全症例におけるアミノ酸分析の検討

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[Introduction]Amino acids such as branched-chain amino acids (BCAA) are usually administered to chronic liver failure patients, but their administration is not recommended in acute liver failure patients. However, few reports have investigated the change in the plasma concentration of amino acids in acute hepatic failure patients in detail.<br>[Purpose]To evaluate plasma amino acid levels in acute hepatic failure.<br>[Materials and Methods]We retrospectively evaluated plasma concentrations of 23 amino acids and clinical courses of acute liver failure patients admitted to our center from 2004 to 2007.<br>[Results]The study comprised 8 patients. All patients met the criteria of fulminant hepatitis, and they comprised 5 men and 3 women with a median age of 38.0 (interquartile range 34.5-40.8) years. The value of total amino acids on admission was extremely high with a median of 10305.0 nmol/ml. In the treatment process, including treatment with plasma exchange or dialysis, total amino acid values decreased, and the values of BCAA showed normal or lower values.<br>[Conclusion]In patients with fulminant hepatitis, the values of most amino acids were high on admission and decreased by various treatments during hospitalization. Further study is required to clarify the timing and method of administration of amino acids.

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