Diabetic renal hypouricemia

DOI
  • SASAKI Norihito
    First Department of Internal Medicine, Tottori University School of Medicine
  • HISATOME Ichiro
    First Department of Internal Medicine, Tottori University School of Medicine
  • ISHIKO Riichiro
    First Department of Internal Medicine, Tottori University School of Medicine
  • URABE Keita
    First Department of Internal Medicine, Tottori University School of Medicine
  • YOSHIDA Akio
    First Department of Internal Medicine, Tottori University School of Medicine
  • KOTAKE Hiroshi
    First Department of Internal Medicine, Tottori University School of Medicine
  • MASHIBA Hiroto
    First Department of Internal Medicine, Tottori University School of Medicine
  • TAKEDA Akira
    Third Department of Internal Medicine, Matsue Red Cross Hospital

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Other Title
  • 糖尿病に合併した腎性低尿酸血症の1例

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Description

A 74-year-old woman was found to have low serum urate concentration(1.93±0.36mg/dl)associated with diabetes. Her urate clearance was elevated(17.7±7.1ml/min)and did not change after administration of pyrazinamide or benzbromarone, but was increased after administration of probenecid. Hypoxanthine clearance was not suppressed by treatment with pyrazinamide, and was increased by probenecid administration. However, hypoxanthine clearance was decreased by treatment with benzbromarone. Xanthine clearance was increased by treatment with probenecid but not affected by treatment with benzbromarone.<BR>We suggest that this patient had a renal abnormality, which may have been due to diabetes,which affected tubular presecretory reabsorption of urate and oxypurine.

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