Immunosuppressive acidic protein and immunosuppressive substance in middle ear effusion. (Third report). Response of macrophage to IS.
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- Kakiuchi H.
- Department of Otorhinolaryngology, Wakayama Medical College
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- Dake Y.
- Department of Otorhinolaryngology, Wakayama Medical College
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- Tabata T.
- Department of Otorhinolaryngology, Wakayama Medical College
Bibliographic Information
- Other Title
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- しん出性中耳炎とＩＡＰ，ＩＳ ＩＩＩ マクロファージに及ぼすＩＳの影響
- Response of Macrophage to IS
- マクロファージに及ぼすISの影響
Description
It was reported that the IS levels in serous middle ear effusion were significantly high and rat IS certainly prolongated the histological inflammation of rat middle ear with OME induced by formalin-killed H. influenzae. In order to reveal the real mechanism of the histological changes, the response of macrophage to IS was examined. The effect of IS on the phagocytic activity of macrophage was not significant, however the PGE2 production of macrophage by IS treatment was considerable. These results suggest that PGE2 induced by macrophage is one of the factors of prolongation of histological inflammation of OME which is caused by formalin-killed H. influenzae.
Journal
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- Ear Research Japan
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Ear Research Japan 19 310-312, 1988
THE JAPAN OTOLOGICAL SOCIETY
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Details 詳細情報について
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- CRID
- 1390282679747217792
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- NII Article ID
- 130004355843
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- ISSN
- 18845797
- 02889781
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
