書誌事項
- タイトル別名
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- Survey on the Phosphorus Concentration in Amlodipine Tablets and Amlodipine OD Tablets
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<p>The phosphorus content of the drug was reported in the United States, and attention was paid to pharmaceutical additives. However, papers surveying the phosphorus content of drugs in Japan have not been reported. We calculated the phosphorous content in dibasic calcium phosphate hydrate (DCPH) or dibasic calcium phosphate (DCP) in amlodipine (AML) and compared the phosphorus content for each formulation. DCPH or DCP was found in all the 104 AML tablets and in 15 of the 78 AML OD tablets. On request, the pharmaceutical company revealed the amounts of DCPH or DCP in 78 of the 104 AML tablets (75.0％) and 9 of the 15 AML OD tablets (60％). The phosphorus content in AML tablets varied among the pharmaceutical companies and it tended to increase with an increase in dose. On the other hand, 63 of the 78 AML OD tablets did not contain DCPH or DCP. Furthermore, the phosphorus content in 9 of the 15 AML OD tablets containing DCPH or DCP was lower than that in AML tablets. Therefore, unnecessary phosphorus load can be avoided in dialysis patients by opting for AML OD tablets rather than AML tablets or opting for low phosphorus content AML tablets.</p>
収録刊行物
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- 医療薬学
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医療薬学 43 (5), 260-266, 2017-05-10
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679751510528
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- NII論文ID
- 130006733801
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- ISSN
- 18821499
- 1346342X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可