書誌事項
- タイトル別名
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- Adsorption Characteristics of Coadministered Drugs to Polystyrene Sulfonate Drugs
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説明
Polystyrene sulfonate drugs (PSS) are likely to adsorb coadministered drugs through ionic and hydrophobic interactions because of their chemical structures. Nine drugs frequently dispensed at our 3 pharmacies to administer with PSS concurrently were selected and examined for their adsorption in vitro to Kalimate® powder in pH 6.8.<br>Cationic drugs in the solution, amlodipine besylate and dilazep hydrochloride hydrate were adsorbed almost totally, while anionic drugs, aspirin, furosemide and losartan potassium were only adsorbed in 0-15%. Non-ionic drugs, allopurinol, nifedipine and prednisolone were adsorbed to different extents, 9, 59 and 84%, respectively in proportion to their hydrophobicity (XLogP3). These data clearly indicate that cationic drugs and highly hydrophobic non-ionic drugs are susceptible to be adsorbed by PSS.<br>The dissolution test of Adalat® L at pH 6.8, pH 4.5 and pH 1.2 in the presence of Argamate® Jelly showed that release of nifedipine was apparently depressed markedly at any pH.<br>We propose that a description directing attention to the interaction with a wide range of drugs is added in the package inserts of PSS to avoid the occurrence of drug interactions.
収録刊行物
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- 医療薬学
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医療薬学 40 (1), 47-53, 2014
一般社団法人日本医療薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679753547264
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- NII論文ID
- 130004894835
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- ISSN
- 18821499
- 1346342X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
