医療従事者の薬物相互作用に対する意識調査―グレープフルーツと薬物の相互作用について―

  • 古割 公二
    神奈川薬物相互作用研究会 聖マリアンナ医科大学東横病院薬剤部
  • 柳川 忠二
    神奈川薬物相互作用研究会 聖マリアンナ医科大学東横病院薬剤部
  • 佐川 賢一
    神奈川薬物相互作用研究会 北里大学病院薬剤部
  • 池田 勉
    神奈川薬物相互作用研究会 済生会若草病院薬剤部
  • 小坂 好男
    神奈川薬物相互作用研究会 日本医科大学付属第二病院薬剤科
  • 依田 啓司
    神奈川薬物相互作用研究会 国際親善総合病院薬剤部
  • 阿部 博
    神奈川薬物相互作用研究会 海老名総合病院薬剤科
  • 佐藤 透
    神奈川薬物相互作用研究会 川崎幸病院薬剤科
  • 河野 博充
    神奈川薬物相互作用研究会 帝京大学医学部附属溝口病院薬剤部
  • 柴田 徹一
    神奈川薬物相互作用研究会 日本薬科大学

書誌事項

タイトル別名
  • Survey on Awareness of Drug Interactions among Medical Professionals-Interaction between Grapefruits and Drugs-
  • Interaction between Grapefruits and Drugs
  • グレープフルーツと薬物の相互作用について

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抄録

Drug interactions broadly fall into two categories : drug-drug interactions, which occur when two or more drugs react with each other, and drug-food/beverage interactions, which occur when drugs react with a food or beverage taken concurrently. These interactions may profoundly affect drug pharmacokinetics, pharmacologic actions and efficacy, and may cause adverse reactions. To avoid the risks of drug interactions, it is important that not only medical professionals but also patients be fully aware of potential interactions, and also that consistent information be given to patients. The achievement of these two objectives can reduce the frequency of the adverse effects and improve outcomes.<BR>We selected the example of the widely discussed interactions between grapefruits and certain drugs and investigated the extent to which medical staff (doctors, nurses, dietitians, and pharmacists) were aware of them and informed their patients about them, by means of a questionnaire. From the findings, it was clear that awareness of the interactions among medical professionals varied greatly and the amount of information given to patients also varied greatly, implying that awareness of the interactions and the information provided to patients on them were both inadequate.<BR>The absence of consistent information will lead to patient confusion and is disadvantageous from a therapeutic viewpoint. We therefore believe that an important role of pharmacists' in drug therapy is to proactively provide appropriate information on drug interactions to medical professionals and patients before they have the chance to occur.

収録刊行物

  • 医療薬学

    医療薬学 31 (12), 1044-1049, 2005

    一般社団法人日本医療薬学会

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