書誌事項
- タイトル別名
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- Compatibility of Wintermin fine granules and magnesium oxide.
説明
The compatibility of Wintermin® fine granules consisting of chlorpromazine phenolphthalinate and magnesium oxide was investigated by sensory test, and the residual amount of chlorpromazine was measured with high-performance liquid chromatography. Although the coloration to pink in the preparation was observed after preservation under medium (20°C, RH 75%) and severe (30°C, RH 92%) conditions, no change in the amount of chlorpromazine under any condition tested was noticed.<BR>It was also found from the chromatogram that a slight amount of phenolphthalein was contaminated in Wintermin®fine granules. Moreover, no change was detected in the compatibility test of chlorpromazine hydrochloride and magnesium oxide under the severe condition.It was, therefore, suggested that the interaction between phenolphthalein and magnesium oxide alkalized by moisture was responsible for the coloration in the preparation of Wintermin®fine granules and magnesium oxide.
収録刊行物
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- 病院薬学
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病院薬学 16 (2), 107-111, 1990
一般社団法人 日本医療薬学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282679754560256
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- NII論文ID
- 130004299115
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- ISSN
- 21859477
- 03899098
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
