トコンシロップ中のエメチン，セファエリンの定量法について

DOI

書誌事項

タイトル別名
  • Quantitative Analysis of Emetine and Cephaeline in Ipecac Syrup.
公開日
1993
DOI
  • 10.5649/jjphcs1975.19.80
公開者
一般社団法人 日本医療薬学会

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説明

We established an easy and quick determination method of emetine (EM) and cephaeline (CP) in ipecac syrup by HPLC, which was carried out by using chloroquine as an internal standard. The calibration plots of these alkaloids showed a good linearity. Semi-preparative HPLC followed by mass-spectrometry was employed and the spectra of EM and CP isolated by preparative HPLC were found to be identical with those of authentic samples. Constant amounts of EM and CP were added to samples and the recovery rates were determined. This method gave a good recovery. The total contents of EM and CP in ipecac syrup from the USA ranged 153.2-184.9 mg/ 100ml and the content ratios (CP/ EM) were 2.6-3.0. These levels were higher than those of the USP standard for ipecac syrup.

収録刊行物

  • 病院薬学

    病院薬学 19 (1), 80-83, 1993

    一般社団法人 日本医療薬学会

キーワード

詳細情報 詳細情報について

  • CRID
    1390282679754600960
  • NII論文ID
    130004103100
  • DOI
    10.5649/jjphcs1975.19.80
  • ISSN
    21859477
    03899098
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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