D‐Galactosamine肝炎ラットにおける肝nascent peptide chainsおよびDNA合成について とくにGlucagon‐InsulinおよびPrednisolone投与の影響
書誌事項
- タイトル別名
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- Synthesis of Nascent Peptide Chains (NPC) and DNA of the liver in D-Galactosamine Hepatitis Rats
- D Galactosamine カンエン ラット ニ オケル カン nasce
- とくにGlucagon-InsulinおよびPrednisolone投与の影響
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Study was conducted to investigate the synthesis of nascent peptide chains (NPC) on polyribosomes which was reported to be the final destinity of the cell in post-ischemic liver as described by BernelliZazzera, A. (1980).<BR>In D-Galactosamine hepatitis rats, the effects of Glucagon-Insulin (G-I) and prednisolone (PSL) on the synthesis of NPC on free and membrane-bonud polyribosomes were determined, as well as the DNA synthesis and c-AMP contents in liver tissues.<BR>A single dose of G-I elevated maximally the synthesis of NPC on both membrane-bound and free ribosomes 12 and 24 hour after the treatment, respectively. Following the increase in the synthesis of NPC, G-I produced a markedly increase in DNA synthesis in liver tissues 24 hour after the administration.<BR>On the other hand, PSL caused a increase in the synthesis of NPC on polyribosomes only 12 hour after the treatment. However, DNA synthesis was markedly inhibited by PSL.<BR>The administration of G-I produced also a prominent increase in the c-AMP levels of liver tissues as early as 6 hour after the treatment.<BR>These results strongly suggest that synthesis of NPC on polyribosomes plays an important role in repair of cell damage caused by D-Gal and that c-AMP may regulate the synthesis of NPC on polyribosomes and DNA synthesis in liver tissues. Hence, G-I and PSL will prevent the progression of hepatic cell necrosis through increased Synthesis of the NPC on polyribosomes.
収録刊行物
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- 肝臓
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肝臓 24 (3), 261-270, 1983
一般社団法人 日本肝臓学会
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詳細情報 詳細情報について
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- CRID
- 1390282679767136000
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- NII論文ID
- 130000879213
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- NII書誌ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL書誌ID
- 2625699
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可