ＨＢｅ抗体常時陽性にもかかわらず急性増悪をきたした慢性肝炎症例の臨床的検討

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タイトル別名
  • Clinical studies on the cases of anti-HBe-positive chronic hepatitis with acute exacerbation
  • HBe コウタイ ジョウジ ヨウセイ ニ モ カカワラズ キュウセイ ゾウアク

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抄録

Out of twenty-two patients with chronic liver disease who had been positive for HBsAg and anti-HBe during more than 6 months, 5 patients with chronic hepatitis showed high elevation of s-GPT. Increase in DNA polymerase (DNA-P) activity and appearance of Dane particles in sera were recognized in 4 of these 5 patients. In one case, values of anti-HBe became transiently judge-pended at the time of exacerbation, though being stationary in remaining 3 cases. In the immunohistological study of a liver biopsy specimen from one of these cases, cytoplasmic HBsAg was diffusely distributed, but HBcAg was rarely recognized. In the fifth case, however, the simultaneous infection with non-A, non-B hepatitis virus in a carrier of hepatitis B virus was suspected, because the patient was transfused in operation about 2 months before the developed acute exacerbation without increase of DNA-P activity. On the other hand, 17 of 22 cases showed normal s-GPT and no appearance of DNA-P activity in their sera.

収録刊行物

  • 肝臓

    肝臓 23 (10), 1133-1140, 1982

    一般社団法人　日本肝臓学会

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