BSP・ICG結合血清蛋白の検討およびその臨床的意義

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タイトル別名
  • Studies of serum binding-protein to Sulfobromophthalein (BSP) and Indocyanine green (ICG), and its clinical estimation
  • BSP ICG ケツゴウ ケッセイ タンパク ノ ケントウ オヨビ ソノ リン

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After intravenous administration, BSP and ICG are rapidly bound to serum protein. For the purpose of identifying the fraction of binding protein for BSP and ICG, column chromatography of sephadex G 200, single radial immunodiffusion in serum containing gels and agarose-gel electrophoresis were performed. The result showed that BSP was mainly bound to albumin and ICG was mainly to lipoprotein, especiallyβ-lipoprotein.<BR>In order to study the influence of plasma protein change on dye clearance, plasma disappearance rate of BSP and ICG were studied in 16 patients with hypoalbuminemia (less than 2.5%), but without proven liver disease, such as nephrotic syndrome, lung cancer, gastric cancer and protein loosing gastroenteropathy. There was high correlation between BSP clearance rate and serum albumin level (γ=-0.603, p<0.01), while the coefficient of correlation between ICG clearance rate and serum albumin level was low (γ=-0.331, p<0.05).

収録刊行物

  • 肝臓

    肝臓 16 (11), 763-769, 1975

    一般社団法人　日本肝臓学会

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