飲酒者の肝臓ミトコンドリアならびにミクロゾーム酵素の量的変動に関する研究

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タイトル別名
  • Studies on the mitochondrial and microsomal cytochromes in alcoholics liver
  • インシュシャ ノ カンゾウ ミトコンドリア ナラビニ ミクロゾーム コウソ ノ

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抄録

The mitochondrial and microsomal cytochromes in human livers were studied in relation to the ethanol metabolism. For this purpose, a micromethod for determining the cytochromes content in small biopsy sample was developed. The results with 62 cases with a variety of liver diseases were as follows; 1) The liver cytochrome a3 content did not significantly change in the drinkers with chronic hepatitis (CH) as compared to that of the non-drinkers, while it slightly decreased in the case of liver cirrhosis (LC), 2) The cytochrome P-450 content significantly increased in the drinkers with CH(P<0.05), while no change was observed in the drinkers with LC, 3) the P-450/b5 ratio of non-drinkers' livers was found to be in linear correlation, while this ratio was variable in the drinkers. The results were discussed in view of the ethanol metabolism in the livers.

収録刊行物

  • 肝臓

    肝臓 18 (12), 943-949, 1977

    一般社団法人　日本肝臓学会

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