A long-term survival case of hepatic epithelioid hemangioendothelioma with lung metastases treated with recombinant interleukin-2

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  • Hoki Toshifumi
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Miyanishi Koji
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Kawano Yutaka
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Yamada Shota
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Harada Kohei
    Division of Radiology, Sapporo Medical University Hospital
  • Hirakawa Masahiro
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Tamura Fumito
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Ishikawa Kazuma
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Takada Kohichi
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Sato Tsutomu
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Sato Yasushi
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Takimoto Rishu
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Kobune Masayoshi
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine
  • Hasegawa Tadashi
    Department of Surgical Pathology, Sapporo Medical University School of Medicine
  • Kato Junji
    Department of Medical Oncology and Hematology, Sapporo Medical University School of Medicine

Bibliographic Information

Other Title
  • Recombinant interleukin-2を投与し6年間経過観察している肺転移を伴う肝類上皮血管内皮腫の1例
  • 症例報告 Recombinant interleukin-2を投与し6年間経過観察している肺転移を伴う肝類上皮血管内皮腫の1例
  • ショウレイ ホウコク Recombinant interleukin-2 オ トウヨ シ 6ネンカン ケイカ カンサツ シテ イル ハイ テンイ オ トモナウ カンルイ ジョウヒ ケッカン ナイヒ シュ ノ 1レイ

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Description

A 37-year-old woman was found in a medical checkup to have liver dysfunction. Abdominal CT scan images demonstrated multiple liver tumors. She was referred to our hospital for examination and treatment. Abdominal enhanced CT scan images showed irregularly spreading hypovascular tumors located in the surface of both hepatic lobes. Needle liver biopsy revealed many atypical cells with positive staining for factor VIII-related-antigen and CD34. The tumor was diagnosed as an hepatic epithelioid hemangioendothelioma (HEHE). She has received intravenous administration of recombinant interleukin-2 (rIL-2) for six years with a reduction in tumor volume. HEHE is a rare tumor which has low malignant potential, also is often unresectable due to multifocal tumors involving both hepatic lobes at the time of diagnosis. There was no generally accepted therapy except surgical resection and liver transplantation. The long-term survival observed in the present case may indicate the effectiveness of rIL-2 for HEHE.

Journal

  • Kanzo

    Kanzo 56 (7), 356-365, 2015

    The Japan Society of Hepatology

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