A case of drug-induced liver injury with prolonged severe intrahepatic cholestasis induced by Ashwagandha

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  • Inagaki Katsuaki
    Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
  • Mori Nami
    Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
  • Honda Yohji
    Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
  • Takaki Shintaro
    Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
  • Tsuji Keiji
    Department of Gastroenterology, Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
  • Chayama Kazuaki
    Department of Gastroenterology and Metabolism, Hiroshima University Hospital

Bibliographic Information

Other Title
  • アシュワガンダによる遷延性高度黄疸を伴った薬物性肝障害の一例
  • 症例報告 アシュワガンダによる遷延性高度黄疸を伴った薬物性肝障害の一例
  • ショウレイ ホウコク アシュワガンダ ニ ヨル センエンセイ コウド オウダン オ トモナッタ ヤクブツセイ カン ショウガイ ノ イチレイ

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Description

<p>A 20-year-old man with social-anxiety disorder was admitted for liver dysfunction accompanied with hyperbilirubinemia. He had used ashwagandha which he imported online in combination with multiple anti-anxiety drugs on his own judgment. He had taken more than twice the recommended dosage for one month before hospitalization. Drug-induced liver injury (DILI) classified as hepatocellular type by Ashwagandha was suspected, due to a score of 8 that is "high possibility" by the DDW-J 2004 DILI diagnostic criteria. Hyperbilirubinemia became exacerbated despite the cessation of ashwagandha and concomitant drugs. Histological findings revealed many canalicular bile plugs. His liver function was normalized after initiation of ursodeoxycholic acid and phenobarbital. Here we reported a rare case of DILI with hyperbilirubinemia caused by Ashwagandha. It is facile to obtain even designated drugs such as ashwagandha by distribution system in the present day. More widely and efficient information system for attention might be needed.</p>

Journal

  • Kanzo

    Kanzo 58 (8), 448-454, 2017

    The Japan Society of Hepatology

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