Two cases of acute liver failure caused by hepatitis A which were negative for serum IgM-HA antibody at the early stage of the onset

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  • Muraoka Masaru
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi
  • Kurosaki Masayuki
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Matsuda Shuya
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi
  • Nakata Toru
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Suzuki Yuichiro
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi
  • Tamaki Nobuharu
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Yasui Yutaka
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Suzuki Shouko
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Hosokawa Takanori
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Nishimura Takashi
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Ueda Ken
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Tsuchiya Kaoru
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Nakanishi Hiroyuki
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Itakura Jun
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Takahashi Yuka
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital
  • Enomoto Nobuyuki
    First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi
  • Izumi Namiki
    Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital

Bibliographic Information

Other Title
  • 発症早期にIgM-HA抗体が陰性であり，再検査によって診断し得たA型肝炎による急性肝不全の2例
  • 症例報告 発症早期にIgM-HA抗体が陰性であり,再検査によって診断し得たA型肝炎による急性肝不全の2例
  • ショウレイ ホウコク ハッショウ ソウキ ニ IgM-HA コウタイ ガ インセイ デ アリ,サイケンサ ニ ヨッテ シンダン シエタ Aガタ カンエン ニ ヨル キュウセイ カンフゼン ノ 2レイ

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Description

Two patients had acute liver failure which was caused by hepatitis A. They were negative for serum IgM-HA antibody on admission. Patient 1 was the 27-year-old woman, and her liver dysfunction recovered by conservative treatment only. She was negative for serum IgM-HA antibody at the fifth day after the onset of the symptoms, but positive at the sixteenth day. Patient 2 was the 63-year-old man. We gave him plasma exchange three times, and rescued him. He was negative for serum IgM-HA antibody at the seventh day after the onset of the symptoms, but positive at the fourteenth day. Patients with acute liver dysfunction may be negative for serum IgM-HA antibody at the early stage of the onset, so we should check their serum IgM-HA antibody again if we suspect that their liver dysfunction is caused by hepatitis A clinically.<br>

Journal

  • Kanzo

    Kanzo 54 (8), 553-558, 2013

    The Japan Society of Hepatology

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