Inhibitory effect of sulfobromophthalein (BSP) on the hepatic uptake and biliary excretion of <SUP>99m</SUP>Tc-pyridoxylideneisoleucine (Pi) in rats

DOI Web Site Web Site
  • KITANI Kenichi
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • KANAI Setsuko
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • MINODA Yukiko
    First Laboratory of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology
  • KAWAGUCHI Shinichiro
    Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
  • IIO Masahiro
    Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
  • SASAKI Yasuhito
    Third Department of Internal Medicine, St. Marianna Medical School

Bibliographic Information

Other Title
  • <SUP>99m</SUP>Tc-pyridoxylideneisoleucine (Pi)のラットに於ける肝・胆道系への排泄-特にsulfobromophthaleinによる干渉-
  • 99m Tc pyridoxylideneisoleucine Pi ノ ラッ

Search this article

Description

Plasma clearance and biliary excretion of an iv injected 99mTc-pyridoxylideneisoleucine (Pi) were compared in control rats and in rats excreting sulfobromophthalein (BSP) into the bile at a maximal rate (Tm). Both plasma clearance and biliary excretion of 99mTc were delayed in rats made in a BSP Tm state compared with control rats. However, when the data were compared with the results previously reported for 99mTc-N-2, 6-(dimethylphenylcarbamoylmethyl) iminodiacetic acid (HIDA, K. Kitani, et al., Jap. J. Nucl. Med. 15: 999, 1978), the inhibitory effect of BSP was less prominent on biliary excretion and conversely, more striking on plasma clearance for 99mTc-Pi.

Journal

  • Kanzo

    Kanzo 20 (6), 604-609, 1979

    The Japan Society of Hepatology

Keywords

Details 詳細情報について

Report a problem

Back to top