Effect of Ethynyl Estradiol on Experimental Intrahepatic Cholestasis

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  • MAEYAMA Toyoaki
    Second Department of Internal Medicine, Kurume University Medical School
  • ANNO Hiroko
    Second Department of Internal Medicine, Kurume University Medical School
  • ABE Hirohiko
    Second Department of Internal Medicine, Kurume University Medical School
  • IKEJIRI Naoki
    Second Department of Internal Medicine, Kurume University Medical School
  • TANIKAWA Kyuichi
    Second Department of Internal Medicine, Kurume University Medical School

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Other Title
  • Ethynyl Estradiolの実験的肝内胆汁うっ滞に及ぼす影響
  • Ethynyl Estradiol ノ ジッケンテキ カンナイ タンジュウ ウ

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Abstract

In female rats pretreated with 0.5mg per 100gm body weight of ethynyl estradiol for seven days, bile flow reduced to 27% of control rats, associated with 24% decrease of bile acid excretion into bile. Reversed correlation was found between a given dose of the ethynyl estradiol and bile flow as well as bile acid excretion. Although continuous infusion of 0.6μM/100gm body weight/min. of taurolithocholate (TLCA) into the femoral vein of rats induced cholestasis, bile flow was increased when 0.083μM/100gm body weight/min. of TLCA was given. However, in rats pretreated with above mentioned dose of ethynyl estradiol, the bile flow was reduced to 52% of nonpretreated control rats with elevation of serum bilirubin by infusion of 0.083μM/100gm body weight/min. of TLCA. Those data suggest that small dose of TLCA, which is not enough for inducing cholestasis, can cause cholestasis when rats are predisposed to it.

Journal

  • Kanzo

    Kanzo 19 (3), 292-298, 1978

    The Japan Society of Hepatology

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