書誌事項
- タイトル別名
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- Effect of Ethynyl Estradiol on Experimental Intrahepatic Cholestasis
- Ethynyl Estradiol ノ ジッケンテキ カンナイ タンジュウ ウ
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抄録
In female rats pretreated with 0.5mg per 100gm body weight of ethynyl estradiol for seven days, bile flow reduced to 27% of control rats, associated with 24% decrease of bile acid excretion into bile. Reversed correlation was found between a given dose of the ethynyl estradiol and bile flow as well as bile acid excretion. Although continuous infusion of 0.6μM/100gm body weight/min. of taurolithocholate (TLCA) into the femoral vein of rats induced cholestasis, bile flow was increased when 0.083μM/100gm body weight/min. of TLCA was given. However, in rats pretreated with above mentioned dose of ethynyl estradiol, the bile flow was reduced to 52% of nonpretreated control rats with elevation of serum bilirubin by infusion of 0.083μM/100gm body weight/min. of TLCA. Those data suggest that small dose of TLCA, which is not enough for inducing cholestasis, can cause cholestasis when rats are predisposed to it.
収録刊行物
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- 肝臓
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肝臓 19 (3), 292-298, 1978
一般社団法人 日本肝臓学会
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詳細情報 詳細情報について
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- CRID
- 1390282679772490624
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- NII論文ID
- 130000874275
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- NII書誌ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL書誌ID
- 1932182
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可