RELEASE OF ADRENALINE FROM ADRENAL MEDULLA BY LARGE DOSE OF ACETYLCHOLINE IN ATROPINIZED DOGS

DOI
  • SHIN Shigeo
    Department of Pharmacology, School of Medicine, Showa University
  • SUNAMI Yumi
    Department of Pharmacology, School of Medicine, Showa University
  • HIRAI Takafumi
    Department of Pharmacology, School of Medicine, Showa University
  • OGUCHI Katsuji
    Department of Pharmacology, School of Medicine, Showa University
  • KOBAYASHI Shinichi
    Department of Pharmacology, School of Medicine, Showa University
  • YASUHARA Hajime
    Department of Pharmacology, School of Medicine, Showa University

Bibliographic Information

Other Title
  • アセチルコリンによる副腎髄質からのアドレナリンの遊離

Search this article

Description

The nicotinic action of acetylcholine was studied from the view point of the haemodynamic effect and the plasma catecholamine concentration in dogs. The blood pressure and heart rate were measured at 0.5 min after intravenous injection of adrenaline (1μg/kg) and acetylcholine (1, 125, 250, 500μg/kg) with pretreatment of atropine (2mg/kg) in anesthetized dogs. The blood samples were collected from femoral vein at 0.5 min after drug administration. The plasma concentration of adrenaline and noradrenaline was measured by using Liquid chromatography. The blood pressure, heart rate and catecholamine concentration were increased with increase in dose of acetylcholine. After bi-lateral adrenolectomy, there were no changes in blood pressure and plasma catecholamine by acetylcholine (500μg/kg) . It is confirmed that the rise in blood pressure by nicotinic action with acetylcholine after pretreatment of atropine is mainly due to the release of adrenaline from adrenal medulla.

Journal

Details 詳細情報について

Report a problem

Back to top