Nivalineの抗Cholinesterase作用

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タイトル別名
  • ACTION OF NIVALINE AS AN ANTI-CHOLINESTERASE
  • Nivaline ノ コウCholinesterase サヨウ

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抄録

Nivaline is an alkaloid extracted from Galanthus nivalis L. and chemically, the same as Galanthamine. Nivaline showed potent anti-cholinesterase activity and used for a remedy of the treatment of myoparalysis clinically, such cases as poliomyelitis and myasthenia gravis etc.<BR>We have studied the relationship between the anti-cholinesterase activity and the effect of Nivaline as a remedy of the treatment of poliomyelitis. The following results were obtained.<BR>1) Cholinesterase (ChE) activity in blood of patients suffering from acute anterior poliomyelitis following the administration of 0.25 mg, 0.5mg and 2.5mg of Nivaline is almost the same as the control.<BR>2) In vitro, 10-4-10-5 M of Nivaline inhibited 50% of the specific and non-specific ChE activity.<BR>3) ChE activity in brain and in liver of rat and mouse following the administration of Nivaline is almost the same as the control.

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