書誌事項
- タイトル別名
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- PHARMACOLOGICAL STUDY ON ACUTE TOXICITY OF MERCURIC CHLORIDE IN MICE
- 急性昇汞(HgCl2)中毒に対する2,3解毒薬の効果
- キュウセイ ショウコウ HgCl2 チュウドク ニ タイスル 2 3 カイ ド
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抄録
Antidotal effects of α-mercaptopropionyl glicine (MG) and 6, 8-dithioctanic acid (lipoic acid; LA) on mercuric chloride-intoxicated mice and histological examination were investigated. Results are as follows.<BR>After administration of mercuric chrolide in the mice were observed for 7 days. The LD50was caluculated by the method of Litchfield-Wilcoxon. The LD50in the mice was 7.7 mg/kg intravenously. Acute toxic symptoms were observed in mice, depressed of spontaneous movements, piloerection, mydriasis, salivation, tremor convulsion, no righting reflex, depressed respiration. Histological findings of kindney in the mercuric chloride treated mice were noticed degeneration of hyaline droplet, hyperemia of cortex and medulla, dystropic calcification in proximal convoluted tubule and Henle's loop.<BR>Antidotal effects of MG and LA on mercuic chloride intoxicated at doses of LD50were noticed decrease of mortality when administrated of combination with mercuric chloride and MG or LA.
収録刊行物
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- 昭和医学会雑誌
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昭和医学会雑誌 37 (5), 449-454, 1977
昭和大学学士会
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詳細情報 詳細情報について
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- CRID
- 1390282679816374144
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- NII論文ID
- 130001823005
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- NII書誌ID
- AN00117027
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- ISSN
- 21850976
- 00374342
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- NDL書誌ID
- 1914133
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可