A case report of McKittrick Wheelock syndrome with a giant rectal villous tumor, leading to acute renal failure and elevation of the creatine phosphokinase level

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  • 高CPK血症と急性腎不全をきたしたMcKittrick Wheelock syndromeの1例
  • 症例 高CPK血症と急性腎不全をきたしたMcKittrick Wheelock syndromeの1例
  • ショウレイ コウCPK ケッショウ ト キュウセイ ジンフゼン オ キタシタ McKittrick Wheelock syndrome ノ 1レイ

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A 68-year-old man experienced diarrhea more than 10 times a day and appetite loss for a week. He had severe dehydration, hypokalemia, hyponatremia and hypochloremia with renal dysfunction and elevation of the creatine phosphokinase level at admission. Despite rapid infusion for recovery from dehydration, his symptoms became more severe, necessitating hemodialysis because of acute renal failure, leading to seizure and disturbed unconsciousness. After remission of his general status, mucous diarrhea persisted 6-8 times a day. Colonoscopy revealed an encircling tumor with a villous structure 1 cm above the dentate line and extending 10 cm upward. McKittrick Wheelock syndrome (MWS) is a rare pathological condition leading to electrolyte disturbance and dehydration by large-volume mucous secretion from villous tumor of the colon. This patient was also diagnosed with MWS and an operation was performed. The postoperative course was uneventful and MWS has not recurred for 1 year and 3 months. We report this rare case of MWS accompanied with electrolyte disturbance and elevation of the creatine phosphokinase level, necessitating hemodialysis.

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