バファリンによると考えられた急性間質性腎炎の1例 免疫担当細胞,サイトカインの分析を加えて

書誌事項

タイトル別名
  • A case of Bufferin induced acute interstitial nephritis. Adding to analysis of immune cells, cytokine.
  • —Adding to analysis of immune cells, cytokine—
  • ―免疫担当細胞,サイトカインの分析を加えて―

抄録

This paper describes a case report of acute interstitial nephritis associated with Bufferin(R). A 15-year-old girl were referred to our hospital due to fever and renal dysfunction. Laboratory findings showed elevation of serum BUN and creatinine, and increased urinary β2-MG excreation. Light microscopic findings of her renal biopsy specimen revealed edema and numerous inflammatory cells in the interstitium, and minor alterations in glomeruli. The interstitial infiltrates consisted mainly of T cells and also monocytes/macrophages. Interstitial cells were labelled with antibodies to interleukin (IL)-1 and tumor necrose factor (TNF). Bufferin(R) was positive by lymphocyte stimulation test . Thus, we considered that this drug was causative in this case. This observation suggests the participation of cell -mediated immune injury in drug induced acute interstitial nephritis .

収録刊行物

詳細情報 詳細情報について

  • CRID
    1390282679834978816
  • NII論文ID
    130004169885
  • DOI
    10.14842/jpnjnephrol1959.34.1195
  • ISSN
    18840728
    03852385
  • PubMed
    1294773
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ