書誌事項
- タイトル別名
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- The effect of elastase on Masugi nephritis of rats.
抄録
Elastase has been known as having elastin lytic action and also as a drug having control action of hyperlipidemia and atherosclerosis. To investigate the action of Elastase on Masugi nephritis, 5 mg (group E5) or 1 mg (group E1) of Elastase and PBS (group E0) as a control were ip injected every day for eight weeks. The rats were unilatelally nephrectomized at 4th week and sacrificed at 8th week. The amount of proteinuria was E0>E1≅E5. Severity of fibrin deposits in glomeruli was E0>E1>E5. Severity of the renal histology was quantitatively evaluated using the enlarged photographs by computerized surface measurement and were E0>E1>E5 in glome-rular sclerosis, cresent and cellular infiltration of tubulo-interstitial tissue. The widening of glomerular tuft and Bowman's capsule were E0≅E1≅E5. These data suggested that Elastase had protective action in the progression of Masugi nephritis and might be useful for human kidney diseases.
収録刊行物
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- 日本腎臓学会誌
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日本腎臓学会誌 30 (11), 1333-1338, 1988
社団法人 日本腎臓学会