Liver Dysfunction in Patients with Systemic Lupus Erythematosus
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- Takahashi Atsushi
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Abe Kazumichi
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Saito Rie
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Iwadate Haruyo
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Okai Ken
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Kobayashi Hiroko
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Kanno Yukiko
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Watanabe Hiroshi
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Ohira Hiromasa
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Katsushima Fumiko
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Saito Hironobu
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
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- Monoe Kyoko
- Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, Japan
書誌事項
- 公開日
- 2013
- 資源種別
- journal article
- DOI
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- 10.2169/internalmedicine.52.9458
- 公開者
- 一般社団法人 日本内科学会
この論文をさがす
説明
Objective We aimed to define the clinical features of liver dysfunction in patients with systemic lupus erythematosus (SLE).<br> Methods The frequency and causes of liver dysfunction were examined in 206 patients with SLE.<br> Results Liver dysfunction was evident in 123 (59.7%) of the 206 patients. Liver dysfunction in patients with SLE can be drug-induced (30.9%) or caused by SLE itself (28.5%), fatty liver (17.9%), autoimmune hepatitis (AIH) (4.9%), primary biliary cirrhosis (2.4%), cholangitis (1.6%), alcohol (1.6%) or viral hepatitis (0.8%), and it tends to be mild except when caused by AIH. Values for aminotransferase were significantly increased when AIH was the cause, whereas alkaline phosphatase (ALP) and γ-glutamyl transpeptidase (γ-GTP) were significantly increased when AIH or drugs were the cause. The liver was already dysfunctional at the time of SLE onset in 56 (45.5%) of 123 patients with liver dysfunction. Neurological involvement was more common among patients with than without liver dysfunction, whereas SLE activity and prognosis did not significantly differ between the two groups.<br> Conclusion Liver dysfunction in the presence of SLE can be caused by many factors, but when extant at the time of SLE onset, either SLE itself or drugs can be the cause. Autoimmune hepatitis should be considered when liver dysfunction is relatively severe.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 52 (13), 1461-1465, 2013
一般社団法人 日本内科学会
