High Serum Thioredoxin Levels Are Reduced after Tonsillectomy in Patients with IgA Nephropathy
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- Nosaki Tsuyoshi
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Uto Hirofumi
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Takami Yoichiro
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Oku Manei
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Fukumoto Mayumi
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Mera Kumiko
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Nishida Chika
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Tokunaga Koki
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Sogabe Atsushi
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Oketani Makoto
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Ido Akio
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
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- Kurono Yuichi
- Department of Otolaryngology Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
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- Tsubouchi Hirohito
- Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan
書誌事項
- 公開日
- 2012
- 資源種別
- journal article
- DOI
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- 10.2169/internalmedicine.51.6021
- 公開者
- 一般社団法人 日本内科学会
この論文をさがす
説明
Objective The role of oxidative stress in IgA nephropathy (IgAN), the most common type of primary glomerulonephritis, is unknown. We evaluated the clinical significance of serum levels of oxidative stress markers, thioredoxin (TRX) and manganese superoxide dismutase (MnSOD), in patients with IgAN.<br> Methods Forty-eight patients with histologically confirmed IgAN and 14 healthy subjects were enrolled in this study. Serum samples from 14 IgAN patients were obtained after tonsillectomy, a procedure hypothesized to be an effective treatment for IgAN.<br> Results Serum TRX levels were significantly higher in patients with IgAN than in healthy subjects (mean [ng/mL]; 49.5 vs.14.4, p<0.001). Serum TRX levels are positively correlated with blood urea nitrogen, serum uric acid and proteinuria, and negatively with estimated glomerular filtration rate (eGFR). In addition, serum TRX levels gradually increased as the severity of renal histology increased. High levels of serum TRX were significantly decreased after tonsillectomy in patients with IgAN (mean [ng/mL]; 55.5 to 41.1, p=0.02). In contrast, serum MnSOD levels did not differ between IgAN patients and healthy subjects, and these levels did not change after tonsillectomy in IgAN patients.<br> Conclusion Serum TRX is associated with IgAN, and tonsillectomy may decrease oxidative stress in IgAN patients, leading to clinical improvement.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 51 (6), 559-565, 2012
一般社団法人 日本内科学会
