Benign Premature Ventricular Complexes from the Right Ventricular Outflow Tract Triggered Polymorphic Ventricular Tachycardia in a Latent Type 2 LQTS Patient

  • Sato Akinori
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Chinushi Masaomi
    School of Health Sciences, Niigata University, Japan
  • Sonoda Keiko
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Abe Akira
    Department of Cardiology, Niigata Minami Hospital, Japan
  • Izumi Daisuke
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan
  • Furushima Hiroshi
    Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Japan

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抄録

A 57-year-old woman showed frequent premature ventricular complexes (PVCs) originating from the right ventricular outflow tract (RVOT), and some of the PVCs triggered polymorphic ventricular tachycardia (PVT). Structural heart diseases were ruled out by conventional cardiac examinations. Radiofrequency catheter ablation was successful in eliminating the PVCs and subsequent PVT. However, epinephrine infusion unmasked her prolonged QT interval, and a genetic analysis revealed a KCNH2 mutation (R694H) as the cause of latent type-2 long QT syndrome (LQTS). This case suggests that latent LQTS may work as an arrhythmogenic substrate of PVT triggered by a benign form of RVOT-PVCs in patients with a structurally normal heart.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 51 (23), 3261-3265, 2012

    一般社団法人 日本内科学会

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