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Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy
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- Koga Takuma
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Kaieda Shinjiro
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Okamoto Masaki
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Masuda Ken
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Fujimoto Kyoko
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Sakamoto Satoshi
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Nakamura Masayuki
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Tominaga Masaki
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Kawayama Tomotaka
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Fujimoto Kiminori
- Department of Radiology, Kurume University School of Medicine, Japan
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- Hoshino Tomoaki
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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- Ida Hiroaki
- Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
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Description
<p>We describe a case of a woman who presented with a persistent cough, general fatigue, and a fever. Interstitial lung disease was rapidly progressive and resistant to high-dose steroid therapy. She tested positive for the presence of anti-melanoma differentiation-associated gene 5 (MDA-5) antibody, although she had no skin manifestations of dermatomyositis. She was eventually diagnosed with unclassifiable idiopathic interstitial pneumonia and was successfully treated with intensive immunosuppressive therapy including intravenous cyclophosphamide. To our knowledge, this is the first report of anti-MDA-5 antibody in a patient with idiopathic interstitial pneumonia. </p>
Journal
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- Internal Medicine
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Internal Medicine 57 (7), 1039-1043, 2018
The Japanese Society of Internal Medicine