Successful Treatment of Rapidly Progressive Unclassifiable Idiopathic Interstitial Pneumonia with Anti-melanoma Differentiation-associated Gene-5 Antibody by Intensive Immunosuppressive Therapy

  • Koga Takuma
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Kaieda Shinjiro
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Okamoto Masaki
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Masuda Ken
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Fujimoto Kyoko
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Sakamoto Satoshi
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Nakamura Masayuki
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Tominaga Masaki
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Kawayama Tomotaka
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Fujimoto Kiminori
    Department of Radiology, Kurume University School of Medicine, Japan
  • Hoshino Tomoaki
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan
  • Ida Hiroaki
    Department of Medicine, Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, Japan

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抄録

<p>We describe a case of a woman who presented with a persistent cough, general fatigue, and a fever. Interstitial lung disease was rapidly progressive and resistant to high-dose steroid therapy. She tested positive for the presence of anti-melanoma differentiation-associated gene 5 (MDA-5) antibody, although she had no skin manifestations of dermatomyositis. She was eventually diagnosed with unclassifiable idiopathic interstitial pneumonia and was successfully treated with intensive immunosuppressive therapy including intravenous cyclophosphamide. To our knowledge, this is the first report of anti-MDA-5 antibody in a patient with idiopathic interstitial pneumonia. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 57 (7), 1039-1043, 2018

    一般社団法人 日本内科学会

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