Mechanisms of Visceral Sensitization and Development of Irritable Bowel Syndrome : Inflammation and Hyperexcitability of the Spinal Nerves

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  • Hamaguchi Toyohiro
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine:Department of Occupational Therapy, Niigata University of Health and Welfare, School of Health Sciences
  • Kanazawa Motoyori
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine
  • Fukudo Shin
    Department of Behavioral Medicine, Tohoku University Graduate School of Medicine

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Other Title
  • 過敏性腸症候群の発生機序 : 消化管知覚過敏に関与する炎症と脊髄神経興奮
  • カビンセイ チョウ ショウコウグン ノ ハッセイ キジョ ショウカカン チカク カビン ニ カンヨ スル エンショウ ト セキズイ シンケイ コウフン

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Irritable bowel syndrome (IBS) is a common disorder characterized by abdominal pain in the setting of altered perception of visceral stimuli. Visceral hyperalgesia occurs in the absence of detectable organic disease in the peripheral organs and may cause normal or physiologic contractions to be perceived as painful. Although the pathogenesis of IBS remains speculative and is probably multifactorial, a prevailing paradigm is that transient noxious events lead to sensitization of the neural pain circuit, despite complete resolution of the initiating event. This opened the door to the study of many other factors that contribute to the clinical expression of these disorders, including visceral hypersensitivity, sensitization, altered mucosal immunity, and dysfunction in brain-gut regulatory processes. New knowledge has been gained in areas of genetics, central nervous system and enteric nervous system neurotransmitters of motility, sensitivity and secretion, the effect of altered mucosal inflammation on cytokine and paracrine activation, and neural sensitization, postinfectious disorders, the influence of psychologic stress on gut functioning. A central concept to these mechanisms is the development of hyperexcitability of neurons in the dorsal horn, which can develop either in response to peripheral tissue irritation or in response to descending influences originating in the brainstem. Taking clinical characteristics and the concept of central hyperexcitability into account, a model is proposed by which abdominal pain from inflammatory, colonic distention stimulus, and conditions of the IBS.

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