CLEAR CELL CARCINOMA OF THE OVARY : Its morphology with a review of the literatures on its origin

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  • 卵巣淡明細胞癌 (clear cell carcinoma of the ovary) : 自験 5 症例の形態学と発生母地に関する考察
  • ランソウ タンメイ サイボウ ガン clear cell carcinoma

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Five cases of clear cell carcinoma of the ovary, ranging from 41 to 73 years of age, have been examined in this study, light-microscopically and histochemically. The findings, thus obtained, were analysed in comparison with those of the other malignant ovarian tumors. So far as our cases are concerned, the clear cell carcinoma develops as a monolocular cystoma, giving an impression of its occurrence with an intimate relationship to the serous and endometrioid cyst. Although the histological features of these tumors are varing in a wide range, we have confirmed that the cystic structure with variable papillary projections is nothing but the fundamental architecture on study by serial sections of the tumor tissue. Various types of tumor cells such as clear cells and dark cells admixed with transitional cells and hobnail cells are demonstrable in the tumor per se, especially the clear cells dominating the histological picture. Those tumor cells, however, are mostly same in the cellular type, since intracytoplasmic glycogen as well as acid mucopolysaccharides, probably sulfomucin in nature, is simultaneously demonstrable on histochemical study, with the morphological and histochemical findings similar to those of serous cystadenocarcinoma, endometrioid carcinoma and malignant mixed Mullerian tumor. Based on these findings with review of literature, we come to a conclusion that clear cell carcinoma may originate from the pluripotential paramesonephric coelomic or surface epithelium of ovary. Furthermore, we are considering that those histological pictures may be characteristic in this tumor. If this is true, the clear cell carcinoma should have a morphological entity among the other types of ovarian cystomas.

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