経ロブドウ糖負荷試験によるβ細胞分泌能および末梢インスリン活性の同時算定法に関する検討

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タイトル別名
  • A Mathematical Approximation of the Beta-cell Response and the Peripheral Insulin Activity after Oral Glucose Loading
  • ケイコウ ブドウトウ フカ シケン ニヨル ベータ サイボウ ブンピノウ オヨ

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We have re-examined Sluiter et al's report in which they proposed a mathematical approximation of two independent parameters, the beta-cell response and the peripheral insulin activity after 100g OGTT. It was confirmed that there exists a straight-line relationship between G and I/G for each individual during the early period after the glucose loading. Furthermore, we were able to deduce a very similar equation to theirs for the corrected insulin response as CIR = I30-100/G30 (G30-70) from the mean slope of the straight-line obtained from data of non-obese healthy subjects. There exists a definite correlation between CIR and insulinogenic index. Also, peripheral insuln activity (A) correlated well with insulin sensitivity indicies which were calculated from the speed of the blood glucose fall following a single intravenous injection of insulin.<BR>By these means, we have observed the following:<BR>1) The more obese person had a higher CIR and a smaller A.<BR>2) There were no specific differences in either of the parameters according to age and sex.<BR>3) CIR and A showed a concomitant decrease, as glucose tolerance diminished. In patients with diabetes mellitus, however, only CIR decreased further when FBS exceeded 120 mg/100 ml.<BR>4) Patients with chronic liver diseases revealed a significantly higher CIR and smaller A, when compared with control subjects who showed the same degree of glucose tolerance.<BR>5) 10 hrs after an oral administration of 2 mg dexamethasone, a significant decrease in A was observed, while 8 of 10 persons showed increases in CIR.

収録刊行物

  • 糖尿病

    糖尿病 20 (6), 720-727, 1977

    一般社団法人 日本糖尿病学会

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