インスリン治療糖尿病妊婦における｀１２５´Ｉ‐インスリン結合抗体の推移と新生児低血糖

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タイトル別名
  • Changes in <SUP>125</SUP>I-insulin Binding Antibodies in Diabetic Pregnant Women on Insulin Therapy and Hypoglycemia in Newborns
  • インスリン チリョウ トウニョウビョウ ニンプ ニ オケル 125I インスリ

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説明

To elucidate whether insulin antibodies in pregnant diabetics are related to changes in insulin requirement during pregnancy, and whether hypoglycemia in newborns of diabetic mothers is influenced by insulin antibodies transferred through the placenta, changes in 125I-insulin percent binding to insulin antibodies were measured at the first, second and third trimesters of pregnancy and at delivery, in 20 deliveries by 17 diabetics treated with insulin.<BR>The free insulin levels in the same serum were also measured for each patient in whom the 125I-insulin binding was decreased more than 5% in the third trimester.<BR>The mean percent of 125I-insulin binding in the 20 diabetic pregnancies was unchanged in the first (21.2%) and second trimester (21.1%), but tended to decrease to 17.6% in the third trimester and to increase to 24.6% after delivery.<BR>The 125I-insulin percent binding of 5 patients with neonatal hypoglycemia was significantly higher than that of the other patients without hypoglycemia (p<0.05).<BR>An increase of free insulin levels was observed in 5 of 11 patients in whom the 125I-insulin percent binding was decreased in the third trimester in contrastwith an increased insulin dosage.<BR>The finding that hypoglycemia tended to occur in the newborns of diabetic mothers with high insulin percent binding to insulin antibody during the third trimester, suggests that maternal insulin antibodies may affect the fetal pancreas.

収録刊行物

  • 糖尿病

    糖尿病 25 (8), 891-898, 1982

    一般社団法人 日本糖尿病学会

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