Ｓｔｒｅｐｔｏｚｏｔｏｃｉｎ少量ひん回投与糖尿病マウスのＡＤＣＣ活性
書誌事項
- タイトル別名
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- Increased antibody-dependent cell-mediated cytotoxicity of spleen lymphocytes from low-dose streptozotocin-induced diabetes in mice.
抄録
Multiple low-dose streptozotocin-induced diabetes in mice is thought to be a model of type 1 (insulin-dependent) diabetes mellitus because it is associated with insulitis. Several investigators have reported that cell-mediated immune response, especially thymic immunity, plays a critical role in the development of this type of diabetes. However, there are no reports concerning antibodydependent cell-mediated cytotoxicity (ADCC) or K-cells. Therefore, we investigated the ADCC of spleen lymphocytes from streptozotocin-induced diabetic mice and compared them with blood glucose levels and insulitis.<BR>Eight-week-old male CD-1 +/+ mice and CD-1 nu/nu mice were studied. Among the CD-1 +/+ mice, increased ADCC and insulitis were found in multiple low-dose streptozotocin-injected mice before diabetes developed and the ADCC increased with the degree of insulitis. However, there was no insulitis or increased ADCC in single high-dose streptozotocin-injected mice or control mice. Among the CD-1 nu/nu mice, increased ADCC and high blood glucose levels were found but there was no insulitis in multiple low-dose streptozotocin-injected mice.<BR>These results suggest that increased ADCC is connected with multiple low-dose streptozotocin injection and may play a pathogenetic role in the development of insulitis in the presence of thymic immunity. Our results also suggest that insulitis enhances the diabetogenic effect of streptozotocin.
収録刊行物
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- 糖尿病
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糖尿病 29 (5), 425-431, 1986
一般社団法人 日本糖尿病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679882683392
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- NII論文ID
- 130004337396
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- ISSN
- 1881588X
- 0021437X
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可