Changes in Anaphylatoxin Levels of Blood Donors During Plateletapheresis and Plasmapheresis Procedures.

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Other Title
  • 血小板及び血しょうアフェレーシス実施時の血液アナフィラトキシン値の変動

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Description

The activation of anaphylatoxins during hemapheresis procedures including 3 plateletapheresis and 2 plasmapheresis procedures was studied. The membrane filtration plasmapheresis procedures using APC-4000 (Asahi) and Autopheresis C (Baxter) generated very high levels of C3a of 1254±332ng/ml and of 1435±310ng/ml, respectively. While, the plateletapheresis procedures including the blood centrifugation steps with MCS (Haemonetics), CS-3000 (Baxter), and Spectra (Cobe) elicited much less C3a generation of mean values of 287ng/ml, 471ng/ml and 418ng/ml, respectively. The obtained plasma products from 5 hemapheresis procedures contained high levels of C3a of 303 to 1116ng/ml. All the hemapheresis procedures did not induce C5a but most platelet concentrates and plasma products contained increased C5a levels of 22 to 29 ng/ml. On the other hand, C4a also increased with two membrane-plasmapheresis procedures for 114 to 606ng/ml even if there is no evidence of classical pathway activation. Finally C3a is a most reliable indicator for complement activation during hemapheresis procedures.

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Details 詳細情報について

  • CRID
    1390282679885263872
  • NII Article ID
    130003706901
  • DOI
    10.3925/jjtc1958.41.224
  • ISSN
    18838383
    05461448
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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