Anti-Ena in a case of delayed hemolytic transfusion reaction.

DOI
  • Shigeta Katsuyoshi
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Kawata Noriko
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Okuda Makoto
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Kato Tadashi
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Ashizawa Miho
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Iguchi Akiko
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Tsukimoto Ichiro
    Division of Blood Transfusion, Toho University School of Medicine, Omori Hospital
  • Hachiya Yoshihiko
    The First Department of Internal Medicine, Toho University School of Medicine
  • Kato Masako
    The First Department of Internal Medicine, Toho University School of Medicine
  • Nagao Nobuo
    Osaka Red Cross Blood Center
  • Senoo Taiko
    Osaka Red Cross Blood Center
  • Uchikawa Makoto
    The Japanese Red Cross Central Blood Center

Bibliographic Information

Other Title
  • 末期肝不全患者に見られた遅発性溶血性輸血副作用様症状と同時に検出された抗Ｅｎ｀ａ´について

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Description

We experienced a patient with a life-threatening suspected delayed hemolytic transfusion reaction (DHTR). The patient was a 73-year-old female with liver cirrhosis. Her blood type was A+, D+C-c+E+e-. She had has 2 pregrancies and a history of 2 transfusions. She received 1 unit of whole blood and 2 units of concentrated red cells for the treatment of anemia (Hb 7.1g/dl) on December 2 and 3, 1992.<br>No irregular antibodies were found before transfusion and crossmatch test showed no significant agglutination by the indirect antiglobulin test. Her hemoglobin level dropped to 1.4g/dl between the day 7 to the day 9 after transfusion without any bleeding signs. At the same time GOT, LDH and T. Bil. levels, increased remarkably. However, no hematuria was seen hematuria. Serological studies showed the presence of strong antibodies against high frequency red cell antigen. The antibody was identified as anti-Ena, which is associated with the MNS blood system. Anti-Ena titer increased 16 to 256 times by the saline method, and 256 to 64, 000 times by the indirect antiglobulin test from the day 9 to day 12 after transfusion. These findings strongly suggested DHTR secondary response. The elution test using cells from her elder sister (also En (a-)) showed the existence of anti-C and anti-e. It is therefore difficult to identify the antibody responsible for the DHTR. Reports of anti-Ena are rare, this being only the second case reported in the Japanese literature.

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Details 詳細情報について

  • CRID
    1390282679885762944
  • NII Article ID
    130003853072
  • DOI
    10.3925/jjtc1958.42.289
  • ISSN
    18838383
    05461448
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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