4℃保存血小板製剤の再評価

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  • Re-evaluation of Platelet Concentrates Stored at 4.DEG.C..

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We evaluated the feasibility of storage of platelet concentrate (PC) at 4°C. Although the number of platelets in PCs decreased during storage at both 4°C and room temperature (RT), PCs stored at 4°C had significantly fewer platelets after 5-day storage, but showed superior platelet aggregation to that of PCs stored at RT. At the same time, β-thromboglobulin (β-TG) release reaction was also detected in PCs stored at 4°C. RANTES, p-selectin and β-TG accumulation during PC storage at 4°C was less than that of PCs stored at RT. Although it is known that no in vitro test has been shown to correlate well with platelet in vivo survival and recovery, our results may indicate that it is worthwhile to re-evaluate the efficacy of PC storage at 4°C.

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  • 日本輸血学会雑誌

    日本輸血学会雑誌 46 (5), 480-486, 2000

    一般社団法人 日本輸血・細胞治療学会

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