A Case of Dasatinib-induced Pleural Effusion Accompanied by Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia, Successfully Treated with Saikanto

DOI Web Site 1 Citations 42 References
  • FUKUDA Tomoaki
    Oriental Medicine Research Center, Kitasato University
  • TSUDA Tokutaro
    Doctoral Program of Medical Science, Kitasato University Graduate School
  • HAYASAKI Tomoyuki
    Oriental Medicine Research Center, Kitasato University
  • OIKAWA Tetsuro
    Oriental Medicine Research Center, Kitasato University
  • HANAWA Toshihiko
    Oriental Medicine Research Center, Kitasato University Doctoral Program of Medical Science, Kitasato University Graduate School

Bibliographic Information

Other Title
  • ダサチニブによる胸水に対し柴陥湯が奏効したフィラデルフィア染色体陽性急性リンパ性白血病の１例
  • 臨床報告 ダサチニブによる胸水に対し柴陥湯が奏効したフィラデルフィア染色体陽性急性リンパ性白血病の1例
  • リンショウ ホウコク ダサチニブ ニ ヨル キョウスイ ニ タイシ サイカントウ ガ ソウコウ シタ フィラデルフィア センショクタイ ヨウセイ キュウセイ リンパセイ ハッケツビョウ ノ 1レイ

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Abstract

We report a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) in whom saikanto was effective against pleural effusion induced by dasatinib, which is a second-generation tyrosine kinase inhibitor. The patient was a 43-year-old female. After she was diagnosed with Ph+ALL, she received imatinib and other chemotherapy. One year later, she started to receive dasatinib because of imatinib intolerance (vomiting and diarrhea). After about seven months of taking dasatinib, she experienced chest/back pain and a cough; at that time her chest x-ray showed right-sided pleural effusion. She consulted our clinic three months later, for treatment of the hydrothorax that frequently recurred. We prescribed saikanto because she presented with epigastric tenderness diagnosed as shokekkyo, and the pleural effusion and clinical symptoms improved remarkably. Because of the good clinical course in this case, we consider that the decrease of pleural effusion was caused mainly by the immunoregulatory and anti-inflammatory activities of saikanto in addition to its activities to alleviate fluid retention.

Journal

  • Kampo Medicine

    Kampo Medicine 62 (5), 664-668, 2011

    The Japan Society for Oriental Medicine

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