セアカゴケグモ(Latrodectus hasseltii)の毒腺抽出物のマウスに対する発痛および全身性作用

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  • 大塚 英治
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences
  • 出崎 克也
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences
  • 宮本(山口) 朋美
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences
  • 野島 浩史
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences
  • 上村 清
    Department of Biodefence Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University
  • 吉田 政弘
    Laboratory of Medical Zoology, Osaka Prefectural Institute of public Health
  • 倉石 泰
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences

書誌事項

タイトル別名
  • Algogenic and systemic effects of venom gland extract from the red back widow spider (Latrodectus hasseltii) in mice

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抄録

The algogenic effects of venom gland extract (VGE) from the red back widow spiders (Latrodectus hasseltii) and its component α-latrotoxin were investigated in mice. Mice were given an intraplantar injection of VGE or α-latrotoxin into the hind paw, and licking of the injected site was assessed as a pain-associated response. The VGE increased dose dependently the licking behavior at doses of 1/300th to 1/30th venom gland. The licking behavior elicited by an injection of VGE at a dose of 1/100th venom gland was significantly suppressed by subcutaneous pretreatment with the opioid analgesic morphine hydrochloride (3 and 10 mg/kg) but not the aspirin-like drugs, such as ketoprofen (10 and 30 mg/kg) and diclofenac sodium (10 and 30 mg/kg). An intraplantar injection of heat-treated VGE did not elicit licking behavior. An injection of α-latrotoxin (30 and 300 ng) markedly increased licking behavior. These findings suggest that an injection of VGE causes severe pain through non-inflammatory mechanisms. It is possible that the algogenic action of VGE is at least partly mediated by α-latrotoxin.

収録刊行物

  • 衛生動物

    衛生動物 54 (2), 161-167, 2003-06-15

    日本衛生動物学会

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