妊婦のGTTとC-peptide反応(CPR)

DOI Web Site

書誌事項

タイトル別名
  • Glucose Tolerance Test (GTT) and Serum C-peptide Immunoreactivity (CPR) in Pregnant Women
  • ニンシン ノ GTT ト C peptide ハンノウ CPR

この論文をさがす

抄録

Generally diabetes mellitus is diagnosed by GTT and insulin response. However, C-peptide may be better parameter in diabetic patients treated with insulin, because insulin antibody interferes with the measurement of endogenous insulin. Our study was carried out from April to August in 1977 on 31 cases of non-pregnant women and 84 cases of pregnant women who had glycosuria, family history of diabetes mellitus or large babies more than 4 kilograms, all cases exclusive of patients in insulin therapy. In these women, oral glucose tolerance test with 50 grams of glucose was performed on fasting early in the morning and the levels of blood sugar (BS) and serum C-peptide irnmunoreactivity (CPR) were determined before and at 30, 60 and 120min. after administration of glucose.<br>Results<br>1) In pregnant women, the time of the maximal CPR response was at 60min. in normal type of GTT, at 60 or 120min. in borderline type and at 120min. in diabetic type.<br>2) The ΔCPR/ΔBS at 30min. is more useful to evaluate diabetes mellitus, because the mean value of 30min, has smaller standard deviation compared with that of 60 min.<br>3) In the 3 groups of patients, the difference of the ΔCPR/ΔBS at 30min. was not significant between normal and borderline type, but significant between borderline and diabetic type statistically. The diagnostic criteria of ΔCPR/ΔBS (30min.) is proposed to be 0.07 for assessment of carbohydrate metabolism.<br>4) There was no characteristic of CPR response to each group.<br>5) A significant correlation was found between ΔCPR/ΔBS and ΔIRI/ΔBS (30min.) (Y=12.4X-0.051, r=0.768), IRI being measured simultaneously.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ