A case of Sertoli cell tumor in a postmenopausal woman

DOI Web Site

Bibliographic Information

Other Title
  • 閉経後に発症したSertoli細胞腫の1例
  • 症例報告 閉経後に発症したSertoli細胞腫の1例
  • ショウレイ ホウコク ヘイケイ ゴ ニ ハッショウ シタ Sertoli サイボウ シュ ノ 1レイ

Search this article

Abstract

Sertoli-Leydig cell tumor belongs to the group of sex cord-stromal tumors of the ovary. They are very rare tumors and account for about 0.2-0.6 % of all ovarian tumors. Age at diagnosis averages 25 years, with 75% of these tumors occurring during the second and third decade of life, and less than 10% occurring either prior to menarche or after menopause. We present a case of a Sertoli cell tumor in a postmenopausal woman with signs of virilization. A 67-year-old nulliparous woman presented to our attention with the chief complaint of abdominal distension. Her past history was endometriosis, gout, hypertension and hepatitis C. Cervical cytology was NILM. A magnetic resonance image scan of the pelvic area revealed a 25 cm complex cystic and solid right pelvic mass. As well, the endometrium of the uterus was unusually thick. Serum estradiol was 163.6 pg/ml and serum testosterone was 5.6 ng/ml. We suspected a hormone producing ovarian tumor and performed an abdominal total hysterectomy, bilateral salpingo-oophorectomy and partial omentectomy. The tumor was cystic and solid right ovarian tumor. The predominant microscopic pattern was albeit or retiform. A mitotic count was 1-2/10 HPFs. The immunohistochemical findings showed α-inhibin, vimentin and PgR were positive, EMA, CEA, AE1/AE3, CK7, CK20, CD30, AFP, ER were negative, MIB-1 was positive in 1% of tumor. Leydig cells were not observed. Final diagnosis was right ovarian tumor, Sertoli cell tumor (intermediate differentiation, borderline malignancy) pT1a NX M0, FIGO stage1A. After the surgery, the level of serum estradiol and testosterone decreased rapidly. The patient was started on follow-up visits without adjuvant therapy and was found to be with no evidence of disease. [Adv Obstet Gynecol, 68(1) : 36-41 , 2016(H28.2)]

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top