6FDAポリイミド中空糸膜の作製と新しい膜型人工肺への応用

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タイトル別名
  • Fabrication of hollow fiber membrane of 6FDA polyimide and design of novel membrane oxygenator.

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説明

A novel asymmetric hollow fiber of 6FDA polyimide has been fabricated for intravascular oxygenator (IVOX) device. A dry/wet phase in-version process has been applied to a spinning process to prepare an asymmetric polyimide hollow fiber. The outer surface of the hollow fiber consisted of an ultrathin skin layer. O2 and CO2 transfer rates of the polyimide hollow fiber were much larger than those determined in presently available polydimethylsiloxane (PDMS) hollow fiber and the transfer rates were similar to those measured in silicone-layer-coated polypropylene (Si-PP) hollow fiber. The hemocompatibility of the polyimide hollow fiber without heparinization has been evaluated in vitro and in vivo. The amount of platelets on the polyimide hollow-fiber surface measured in vitro was less than that on PDMS hollow fiber and Si-PP hollow fiber. The formation of thrombus estimated in vivo was not found. This means that the asymmetric polyimide hollow fiber shows excellent hemocompatibility.

収録刊行物

  • 人工臓器

    人工臓器 27 (1), 278-282, 1998

    一般社団法人 日本人工臓器学会

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