A STUDY OF INSPIRATORY RESISTANCE OF DRY POWDER INHALER OF AGENTS FOR ASTHMA CONTROL

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  • Suda Shigeaki
    Chest Institute of Technology, Chest M.I., Inc.
  • Konno Rio
    Chest Institute of Technology, Chest M.I., Inc.
  • Kurosawa Hajime
    Center for Environmental Conservation and Research Safety, Tohoku University; Department of Occupational Health, Tohoku University Graduate School of Medicine
  • Tamura Gen
    Airway Institute in Sendai, Co. Ltd.

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Other Title
  • 気管支喘息の長期管理薬として使用されるドライパウダー吸入器の吸気抵抗
  • キカンシ ゼンソク ノ チョウキ カンリヤク ト シテ シヨウ サレル ドライパウダー キュウニュウキ ノ キュウキ テイコウ

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<p>Objective: Because dry powder inhalers (DPI) aerosolize agents by means of inspiration of patients themselves, inspiratory resistance of DPI is an important factor for increasing inhalation efficiency. Therefore, we measured inspiratory resistance of DPI of agents for asthma control.</p><p>Methods: Using Flow/Volume Simulator, when setting flow rates at 6, 30, 60, 90, and 120L/min, we read off suction pressures and find inspiratory resistances by calculation (=suction pressure/flow rate) at each flow rate.</p><p>Results: In all DPI, inspiratory resistance increases with the increasing flow rate. To maintain flow rate of 60L/min, suction pressure of around 20-cmH2O for Diskus® and Ellipta®, between 35- and 45-cmH2O for Turbuhaler ®, and about 60-cmH2O for Twisthaler® were needed.</p><p> Conclusion: It is suggested that we should instruct patients to inhaler DPI based on inspiratory resistance of the DPI.</p>

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