Developmentof new biomedical materials

DOI
  • NAKAZONO M.
    Department of Urology, The Second Tokyo National Hospital
  • KOMAI T.
    Univ. Hokkaido, Dev. Science, Div. Polymer Chemistry

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Other Title
  • 新しい人工生体材料の開発

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Description

Based upon an experimental hypothesis that an ideal biomedical material should meet the following conditions: 1) proper tissue regeneration in a proper period, 2) complete replacement by reciepients tissue, 3) no cartinogenicity and 4) sufficient functions of the regenerated organs, we have performed several experimental studies before. Our standpoints are that a well controlled dissolvable synthetic or modified natural material might meet these conditions and we expect to be able to selectively tailor materials and introduce new properties by chemical or enzymatic treatments.<br>We choosed the bovine pericardium as original material and performed several kinds of chemical treatments on it.<br>Reconstractions of rabbit bladders were performed with these chemically treated bovine pericardiums after 70% resection of natural urinary bladder. Aceton pretreated 70% acetic anhydride and 30% acecti acid treated bovine pricardium showed acceptable resulst in substitution of the bladder tissue. Methylated and methyl-acetylated bovine pericardiums were also expected good biomedical materials in this study.

Journal

  • Jinko Zoki

    Jinko Zoki 5 (5), 271-275, 1976

    JAPANESE SOCIETY FOR ARTIFICIAL ORGANS

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