THE CORRELATION BETWEEN THE EXACERBATION OF BRONCHIAL ASTHMA AND PICORNAVIRUS(HUMAN RHINO VIRUS)INFECTION : IN THROAT GARGLES BY RT-PCR

DOI 3 Citations 22 References
  • Kuga Hideki
    Department of Public Health, University of Showa School of Medicine
  • Hoshiyama Yoshiharu
    Department of Public Health, University of Showa School of Medicine
  • Kokubu Fumio
    First Department of Infernal Medicine, University of Showa School of Medicine
  • Imai Toshimichi
    First Department of Infernal Medicine, University of Showa School of Medicine
  • Tokunaga Hisahiro
    First Department of Infernal Medicine, University of Showa School of Medicine
  • Matsukura Satoshi
    First Department of Infernal Medicine, University of Showa School of Medicine
  • Kawaguchi Miou
    First Department of Infernal Medicine, University of Showa School of Medicine
  • Adachi Mitsuru
    First Department of Infernal Medicine, University of Showa School of Medicine
  • Kawaguchi Takeshi
    Department of Public Health, University of Showa School of Medicine

Bibliographic Information

Other Title
  • 成人の気管支喘息の急性増悪におけるピコルナウイルス(ライノウイルス)感染の関与 : RT-PCR法を用いた検討
Published
2000
DOI
  • 10.15036/arerugi.49.358
Publisher
Japanese Society of Allergology

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Description

Viral infection is one of important factors to cause the exacerbation of bronchial asthma. We have investigated 167 adults of asthmatics to clarify the correlation between viral infection and exacerbation of asthma. Patients were classificated to four group by the symptoms of common cold and asthma attack. Furthermore, We have examined Picornavirus and Human rhino virus RNA from throat gargles of patients using RT-PCR(reverse transcription-polymerase chain reaction)method. Forty of 65(61.5%)asthmatics with common cold revealed asthma attack and common cold was significantly associated with acute exacerbation of asthma(p<0.01). We identified Picornavirus RNA, which include 113 of Human rhino virus serotypes and enterovirus, from the samples of 16 of 52(30.8%)patients who had acute exacerbation.It was significantly higher than the detection rate of viral RNA from patient without asthma attack. Furthermore, we analyzed Human rhino virus RNA from the same samples by RT-PCR and 93.7% of Picornavirus were identified as Human rhino virus. Taken together, these findings suggest that common cold is significantly associated with the exacerbation of bronchial asthma. Human rhino virus infection might be one of important virus in this procedure.

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