THE EFFECT OF PARTICLE SIZE AND AMOUNT OF INHALATION ON THE PULUMONARY FUNCTION TESTSN IN ASTHMATIC CHILDREN

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  • 小児気管支喘息発作の治療における吸入器の粒子径及び吸入量の違いによる呼吸機能改善の検討
  • ショウニ キカンシ ゼンソク ホッサ ノ チリョウ ニ オケル キュウニュウキ ノ リュウシケイ オヨビ キュウニュウリョウ ノ チガイ ニ ヨル コキュウ キノウ カイゼン ノ ケントウ

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Abstract

The effect of three nebulizers, Nisshou and LC plus, were compared by the particle size and amount of inhalation. The improvement of FEV_1 at 15 minutes after the inhalation was significantly higher in LC plus than Nisshou (MMD : 7.43um, 10.76um). The amount of inhlation were compared between Nisshou with/without Y tube and LC plus nebulizer(R) with/without LC valve system. Nisshou nebulizer with Y tube and LC plus nebulizer with LC valve systems were significantly better than that of LC plus nebulizer without LC valve system. Small loss of inhalation gave us better efficacy. The urinary excretion of disodium cromoglycate (DSCG) was highest in LC plus with LC valve system, Nisshou with Y tube and lowest in Nisshou without Y tube. The elecctric nebulizers produced better in MMD of 5um and a smaller loss of inhalation. These results suggested that MMD less than 5um and small loss from nebulizer are very important for inhalation therapy.

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