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- 大山口 渥
- 京都大学結核胸部疾患研究所内科学第2部門
書誌事項
- タイトル別名
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- STUDIES ON THE MECHANISMS OF TUBERCULIN HYPERSENSITIVITY II. Non-dialyzable Transfer Factor
- ツベルクリン アレルギー ニカンスルケンキュウ 2 ウケミ デンタツ インシ
この論文をさがす
説明
There have been numerous reports on the transfer factor (TF) of delayed-type hypersensitivity, but there are still unsolved problems about its mechanisms. The experiments reported herein wereperformed in order to clarify the transfer mechanisms of tuberculin-type hypersensitivity (TTH). Usedas a TF was the non-dialyzable fraction of the extract obtained from spleen cells of guinea pigs vaccinated and challenged (VC group) with heat-killed BCG.<BR>1. A fraction which showed TTH-transfer activity was isolated from the spleen extract of the VC group by column chromatography using a Sephadex G-75. It's molecular weight was 15, 000- 67, 000.<BR>2. The low molecular fraction of TF did not contain H37Rv antigen or an antibody to H37Rv.<BR>3. Recipient animals intravenously injected with the TF showed a positive skin reaction to PPDon the 3rd day, but the reaction was negative one week after the injection.<BR>4. TTH was transferred to normal recipients with thymocytes or spleen cells from normal animalsincubated with TF in vitro for 24 hours, but not with the lymphnode cells of those animals.<BR>It was demonstrated that TTH could be transferred to normal recipients by thymocytes orspleen cells treated with TF in vitro. This results suggests that normal T cells are sensitized throughthe same process in recipient animals injected with TF.
収録刊行物
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- 結核
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結核 57 (4), 225-232, 1982
一般社団法人 日本結核病学会
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詳細情報 詳細情報について
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- CRID
- 1390282679976892288
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- NII論文ID
- 130001416746
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- NII書誌ID
- AN00073442
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- ISSN
- 18842410
- 00229776
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- NDL書誌ID
- 2487690
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- PubMed
- 7109421
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可