Autologous Tumor-specific Immunotherapy for Recurrent Malignant Melanoma of the Nasal Cavity
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- Nishiura Yuichirou
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
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- Sakamoto Kikuo
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
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- Mihoki Takao
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
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- Takane Youko
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
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- Maeda Akiteru
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
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- Miyajima Yoshimi
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
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- Nakashima Tadashi
- Department of Otolaryngology-Head and Neck Surgery, Kurume University School of Medicine
Bibliographic Information
- Other Title
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- 再発鼻腔悪性黒色腫に対する細胞免疫療法
- サイハツ ビクウ アクセイ コクショク シュ ニ タイスル サイボウ メンエキ リョウホウ
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Description
Malignant melanoma usually occurs in tissues containing large numbers of melanocytes, such as the skin, mucosa and eye, and is one of the most highly malignant tumors known. No satisfactory treatment results have ever been reported. We report here an effective course of immunotherapy consisting of the local injection and intra-venous administration of autologous tumor-cell-stimulated cytotoxic T lymphocytes in a patient with recurrent malignant melanoma. The patient was a 45-year-old woman. She had been diagnosed as having malignant melanoma in 1996 and under went radio-chemotherapy at our hospital. Seven years later, recurrences were recognized in bilateral nasal cavities. Following systematic chemotherapy, 23 local injections of cytotoxic T lymphocytes were performed. Mediastinal lymphonode metastasis was recognized in March, 2004, so 15 additional intravenous administrations of cytotoxic T lymphocytes were performed. At present, no obvious regrowth has been recognized. Immunotherapy using cytotoxic T lymphocytes may be a useful strategy for controlling recurrent malignant melanoma.
Journal
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- Nippon Jibiinkoka Gakkai Kaiho
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Nippon Jibiinkoka Gakkai Kaiho 109 (11), 781-784, 2006
Japanese Society of Otorhinolaryngology-Head and neck surgery
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Details 詳細情報について
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- CRID
- 1390282679984171520
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- NII Article ID
- 10018561610
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- NII Book ID
- AN00191551
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- ISSN
- 18830854
- 00306622
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- NDL BIB ID
- 8583944
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed